Thermal study of four irradiated imidazoline derivatives in solid state
| dc.contributor.author | Marciniec, Barbara | |
| dc.contributor.author | Kozak, Maciej | |
| dc.contributor.author | Naskrent, Marek | |
| dc.contributor.author | Dettlaff, Katarzyna | |
| dc.contributor.author | Ogrodowczyk, Magdalena | |
| dc.contributor.author | Stawny, Maciej | |
| dc.contributor.author | Wachowski, Leszek | |
| dc.date.accessioned | 2010-03-10T15:32:36Z | |
| dc.date.available | 2010-03-10T15:32:36Z | |
| dc.date.issued | 2007 | |
| dc.description.abstract | Four imidazoline derivatives: antazoline (AN), naphazoline (NN), tymazoline (TM), xylometazoline (XM), in the form of hydrochlorides in solid phase have been subjected to high energy e-beam irradiation from an accelerator (10 MeV) at a dose varied from 25 to 200 kGy. The effects of the irradiation have been assessed by DSC, X-ray diffraction, FTIR, EPR and TLC. The standard sterilisation dose of 25 kGy has been found to produce changes in the properties of one derivative (XM), two other ones (AN and TM) have been found sensitive to doses >100 kGy, whereas NN has been resistant to irradiation in the whole range studied (25–200 kGy). EPR results indicated that the changes taking place in the therapeutic substances studied are related to radical formation. The irradiation induced changes in colour, a decrease or increase in the melting point, changes in the XRD pattern, small changes in the shape of FTIR peaks and the presence of radiolysis products. The XM compounds cannot be sterilised by irradiation because of the radiation induced changes in its physico-chemical properties. | pl_PL |
| dc.identifier.citation | Journal of Thermal Analysis and Calorimetry vol. 88(2) 2007, pp. 337-342 | pl_PL |
| dc.identifier.issn | 1388-6150 | |
| dc.identifier.issn | 1572-8943 | |
| dc.identifier.uri | http://hdl.handle.net/10593/193 | |
| dc.language.iso | en | pl_PL |
| dc.publisher | Springer Netherlands | pl_PL |
| dc.subject | antazoline | pl_PL |
| dc.subject | DSC | pl_PL |
| dc.subject | EPR | pl_PL |
| dc.subject | FTIR | pl_PL |
| dc.subject | naphazoline | pl_PL |
| dc.subject | TLC | pl_PL |
| dc.subject | tymazoline | pl_PL |
| dc.subject | XRD | pl_PL |
| dc.subject | xylometazoline | pl_PL |
| dc.title | Thermal study of four irradiated imidazoline derivatives in solid state | pl_PL |
| dc.type | Artykuł | pl_PL |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- M. Naskrent 2007 Thermal study of four imidazoline derivatives in solid state.pdf
- Size:
- 1.16 MB
- Format:
- Adobe Portable Document Format
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.75 KB
- Format:
- Item-specific license agreed upon to submission
- Description: