The phaseness of human biological development assesse with the use of selected physicochemical methods
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Date
2000
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Adam Mickiewicz University Faculty of Biology
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Abstract
The principal idea of the work was to show a new, original method of description
of the phenomena of human biological development with the use of nonstandard
research methods so far unused in the ontogenetic studies in regard to
the stable and involutional phases of ontogenesis. The main purpose of the work
was to assess with selected methods individual reactions of a human organism
in ontogenesis against the development of the population. Two research
methods were selected. They were subsequently used to show individual reactions
of a single human organism against the phenotypic variability characterising the
population. The research methods employed are based on the physical and chemical
properties of biological cells (the Electrophoretic Mobility of Cell Nuclei
(EMN) method) as well as on the physical properties of selected physical parameters
describing the properties of biological structures (the Nuclear Magnetic
Resonance (NMR) spectroscopy method). One of the objectives of the study was
to corroborate the applicability of the EMN index method as an adequate criterion
1 A summary of the thesis submitted for the degree of Doctor of Sciences in Adam Mickiewicz
University, PoznaƱ 1999. Professor conferring the degree: Joachim Cie lik. The title of the thesis:
The phaseness of human biological development assessed with the use of selected physicochemical
methods .
136 Z. Czapla
of biological age estimation in each phase of ontogenesis. High sensitivity of the
EMN index made it possible to check to what extent a reaction of an individual,
resulting from the operation of selected factors increasing the risk of premature
death (nicotinism, alcoholism), would permit to assess the deviation of this individual
organism from the theoretical course of its ontogenesis determined with
the EMN method. Another task under the study involved checking to what degree
the ontogenetic development curve in selected subject groups (alcoholics, smokers
and non-smokers) determined with the EMN method deviated from the
control curve.
The principal research tasks regarding the methods of the Nuclear Magnetic
Resonance spectroscopy involved attempts to find a new physical parameter, which
could serve as a measure of the advancement of certain biological processes
accompanying human ontogenesis. In other words an attempt was made to find
a physical parameter which could become a new criterion of human biological age
estimation regardless of the phase of ontogenesis.
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Keywords
biological age, EMN index, relaxation time, Nuclear Magnetic Resonance, phase of ontogeny, aging
Citation
Variability and Evolution, 2000, Vol. 8, pp. 135-141