Base-catalyzed addition of silylacetylenes to ketones: a route to protected tertiary propargyl alcohols
| dc.contributor.author | Kuciński, Krzysztof | |
| dc.contributor.author | Łuczak, Alicja | |
| dc.contributor.author | Mankouski, Aliaksei | |
| dc.contributor.author | Hreczycho, Grzegorz | |
| dc.date.accessioned | 2024-06-17T12:15:56Z | |
| dc.date.available | 2024-06-17T12:15:56Z | |
| dc.date.issued | 2023-05-07 | |
| dc.description | This is the Accepted Version of the following article: Krzysztof Kuciński, Alicja Łuczak, Aliaksei Mankouski, Grzegorz Hreczycho, Base-catalyzed addition of silylacetylenes to ketones: a route to protected tertiary propargyl alcohols, Organic Chemistry Frontiers, 2023, 10, 2752-2759, DOI: 10.1039/D3QO00579H, which has been published at https://pubs.rsc.org/en/content/articlelanding/2023/qo/d3qo00579h#!divAbstract. In accordance with the RSC's publishing policy and the fact that the above-mentioned article has already been published via open access, the author of the manuscript has the right to publish the Author Accepted Manuscript version in an open repository. | |
| dc.description.abstract | The base-catalyzed addition of alkynylsilanes to ketone derivatives enables the formation of various silyl-protected propargylic alcohols. Commercially available and inexpensive potassium bis(trimethylsilyl)amide (KHMDS) serves as an efficient transition metal-free catalyst and permits the functionalization of a variety of derivatives, including pharmaceuticals and biorelevant compounds. Overall, the presented system complements classical routes to protected tertiary propargylic alcohols that mainly rely on stoichiometric processes or fluoride-mediated reactions. | |
| dc.description.sponsorship | This work was supported by a National Science Centre (Poland) Grant UMO-2021/43/D/ST4/00132 (K.K.). This work was supported by the Adam Mickiewicz University (KK-ID-UB project no. 038/04/NŚ/0001). | |
| dc.identifier.citation | Organic Chemistry Frontiers | |
| dc.identifier.uri | https://hdl.handle.net/10593/27734 | |
| dc.language.iso | en | |
| dc.publisher | The Royal Society of Chemistry | |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.title | Base-catalyzed addition of silylacetylenes to ketones: a route to protected tertiary propargyl alcohols | |
| dc.type | info:eu-repo/semantics/article |