Please use this identifier to cite or link to this item: https://hdl.handle.net/10593/193
Title: Thermal study of four irradiated imidazoline derivatives in solid state
Authors: Marciniec, Barbara
Kozak, Maciej
Naskrent, Marek
Dettlaff, Katarzyna
Ogrodowczyk, Magdalena
Stawny, Maciej
Wachowski, Leszek
Keywords: antazoline
DSC
EPR
FTIR
naphazoline
TLC
tymazoline
XRD
xylometazoline
Issue Date: 2007
Publisher: Springer Netherlands
Citation: Journal of Thermal Analysis and Calorimetry vol. 88(2) 2007, pp. 337-342
Abstract: Four imidazoline derivatives: antazoline (AN), naphazoline (NN), tymazoline (TM), xylometazoline (XM), in the form of hydrochlorides in solid phase have been subjected to high energy e-beam irradiation from an accelerator (10 MeV) at a dose varied from 25 to 200 kGy. The effects of the irradiation have been assessed by DSC, X-ray diffraction, FTIR, EPR and TLC. The standard sterilisation dose of 25 kGy has been found to produce changes in the properties of one derivative (XM), two other ones (AN and TM) have been found sensitive to doses >100 kGy, whereas NN has been resistant to irradiation in the whole range studied (25–200 kGy). EPR results indicated that the changes taking place in the therapeutic substances studied are related to radical formation. The irradiation induced changes in colour, a decrease or increase in the melting point, changes in the XRD pattern, small changes in the shape of FTIR peaks and the presence of radiolysis products. The XM compounds cannot be sterilised by irradiation because of the radiation induced changes in its physico-chemical properties.
URI: http://hdl.handle.net/10593/193
ISSN: 1388-6150
1572-8943
Appears in Collections:Artykuły naukowe (WF)

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